Protease Inhibitors


Protease Inhibitors can significantly boost the success rate of treatment.

The length of your treatment will be determined using response guided therapy. Tests will be done at various times throughout treatment to see how well you are responding. This ensures that you don't have to stay on treatment any longer than necessary.



What is it and who is it for?

Simeprevir is the latest protease inhibitor to become available in Scotland. It can be prescribed for any Hepatitis C genotype. It is a pill taken once daily with food.

How long does treatment take?

Simeprevir is taken for 12 weeks alongside pegylated interferon and Ribavirin, which is taken for either 24 or 48 weeks depending on your genotype and other factors, such as whether you have previously not responded to treatment or relapsed.

If you have genotype 1 or genotype 4 infection and are intolerant to or ineligible for interferon treatment you may be treated with simeprevir alongside sofosbuvir for 12 weeks.

Are there any side effects?

You may experience side effects such as fatigue, headache, flu like symptoms nausea or anaemia. However, for most people side effects with simeprevir are mild.

Using protease inhibitors with some drugs (such as diazepam) can dramatically increase the effect of that drug. If used without consultation with a medical practitioner this could be life threatening.

Hepatitis C Scotland

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